Research Chemical Designation & Liability

Compounds indexed in the MinMaxMuscle archive are strictly for laboratory research and development. They are NOT approved for human consumption. Theoretical dosing data is aggregated from clinical literature and must not be construed as medical instruction. Professional medical consultation is mandatory prior to any research application.

Full Disclaimer
Archive Identifier

MK-677

Growth Hormone Secretagogues

Molecular Dossier

  • Rank Index: 54
  • Status: FDA Category 2
  • What does this mean?
  • Molecular Structure: MW: 624.77 g/mol | Formula: C27H36N4O5S | CAS: 159634-47-6

About MK-677

Non-peptide ghrelin receptor agonist that stimulates pituitary GH secretion in a pulsatile pattern. Orally bioavailable. Clinical trials show significant increases in IGF-1 and GH with once-daily dosing. Associated with improved sleep quality (slow-wave), increased lean mass, and improved bone density in elderly subjects.

Clinical Focus

Sustained GH & IGF-1 Elevation, Sleep Quality, Body Composition

Archival Aliases

Ibutamoren, MK-0677, L-163,191

Frequently Asked Questions

Clinical Data Matrix

Parameter Clinical Value
Molecular Weight MW: 624.77 g/mol | Formula: C27H36N4O5S | CAS: 159634-47-6
Primary Pathway Growth Hormone Secretagogues
Research Phase FDA Category 2

Clinical Pros

  • Highly selective receptor modulation
  • Documented efficacy in Phase II trials
  • Minimal systemic cross-reactivity

Research Limitations

  • Limited long-term human data
  • Strict storage and reconstitution requirements
  • Potential for acute homeostatic feedback loops

Community Discussion

Share your questions and experiences with other researchers in the forum.

Discuss in Forum

Clinical Reference Nodes

[REF 1] pubmed.ncbi.nlm.nih.gov
[REF 2] pubmed.ncbi.nlm.nih.gov
[REF 3] pubmed.ncbi.nlm.nih.gov

Data Verified: 2026-04-14

Synergistic Matrix